Cerberus
Weak to water +40%
Best in slot
The best setup using every item in the game, at 99s with potions and the best prayer.
Melee
Best here
Scythe of vitur · Holy blessing
Ranged
Twisted bow · Seeking dragon arrow
Magic
Tumeken's shadow · Holy blessing
Other options by slot
The best melee pick for each slot and the next best options. Each percentage is the DPS you lose by swapping in just that item against Cerberus.
Mechanics
All three of her attacks hit up to 23, and the right prayer blocks them if it's on before the attack launches.
Her first attack and every tenth one is a triple: magic, ranged, then melee. Below 400 health she summons three souls every seventh attack (red melee, blue magic, green ranged) that attack west to east. An unprotected soul deals 30, a protected one drains 30 prayer. Below 200 she drops lava pools that deal 10 when they appear and 15 every two ticks if you stand in one.
Which style: Melee, crush in particular. Ranged works well too, especially a twisted bow.
From the OSRS Wiki, CC BY-NC-SA 3.0.
Inventory
The OSRS Wiki's own “Melee” setup for Cerberus, slot for slot.
Crimson kisten
Melee weapon to swap to
Divine super combat potion(4)
Boosts Attack, Strength and Defence, and holds the boost for five minutes
Prayer potion(4)×6
Restores prayer points
Spectral spirit shield
Melee gear to swap into
Emberlight
Two special attacks can take its Defence from 100 to 68
Monkfish×14
Heals 16
Teleport to house (tablet)
Takes you home when the trip is done
Nature rune
Runes for your spells
Book of the Dead
Lets you raise thralls: resurrection spells need it worn or in your inventory
Divine rune pouch
Holds the runes for your spells in one slotThe wiki's own setups
Equipment and inventory as the OSRS Wiki's strategy page lists them, slot for slot. These are what people actually take; the solved kits above are what the maths prefers. The inventory drawn above is the one with the “Melee” gear, so that card shows only its equipment.
Ranged
500
Melee
Required: 91 Slayer · A slayer task of Cerberus or hellhounds (required to inflict damage)
What it drops
68 drops, with rates from the OSRS Wiki. Open this boss in the planner for what a kill is worth at today's prices.
What it defends with
Combat tasks
6 tasks worth 26 points. Open the planner to track the ones you have done.
Elite
4 tasks
4 points each
Master
2 tasks
5 points each